Mechanisms of inverse agonist action at D2 dopamine receptors
نویسندگان
چکیده
منابع مشابه
Mechanisms of agonist action at D2 dopamine receptors.
In this study, we investigated the biochemical mechanisms of agonist action at the G protein-coupled D2 dopamine receptor expressed in Chinese hamster ovary cells. Stimulation of guanosine 5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding by full and partial agonists was determined at different concentrations of [35S]GTPgammaS (0.1 and 10 nM) and in the presence of different concentration...
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1. The activities of a range of agonists at D2(long) dopamine receptors expressed in CHO cells have been determined in ligand binding and in a functional assay, the stimulation of [35S]-GTPgammaS binding. 2. For several agonists (apomorphine, dopamine, pergolide, quinpirole, NPA, ropinirole, talipexole) binding in the absence of added guanine nucleotides was best described in terms of interacti...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2005
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0706073